OneWalk. One Day. For All Cancers…
We walk because we can’t walk away!

Paul Alofs

Dear OneWalk Participants,

For over a decade, women and men, just like you, have laced up their shoes and walked for The Princess Margaret. They have walked so that we could make great strides against women’s cancers. They took on the big bold challenge of both walking a great distance and raising an amazing amount of money. They believed in the work of our leading researchers and clinicians at the Princess Margaret Cancer Centre, one of the top 5 cancer research centres in the world. Their hard work and passion for the cause resulted in over $145 million being raised to support the world-leading work of Dr. Tak Mak and his team, the creation of the first in-hospital survivorship program and many, many clinical enhancements…all focused on increasing survivorship and supporting patients. They walked because they could not walk away.

For many of you who know us, we never stand still at The Princess Margaret…we will not stand still until we have conquered all cancers. We have listened to our community, we have listened to our doctors, and most of all, we have listened to cancer patients and their families. We recognize that women and men are diagnosed with many different types of cancer. We know that the leading cause of death is lung cancer and this is true for both women and men. We know that the most prevalent forms of cancer in women are breast, lung, colorectal and uterine, in that order. We wanted to continue our fight to walk to conquer all types of cancers so that no one is left out or feeling that their cancer is any less important. So this year, we're continuing the Rexall OneWalk to Conquer Cancer. It’s onewalk, on one day, for all cancers.

In 2016 the walk is on Saturday September 10th. I hope you will commit to walking 25 km and raising the $1500. We will support you all along the way. I know you will enjoy the enhanced festival atmosphere along the route and at the finish line. You won’t want to miss it. Colored flags from all of the different types of cancer will form an emotional bond as you complete your journey.

Now is the time for all of us to walk together…because we can’t walk away!

Veteran walkers, I ask you to keep walking. You know the impact you have made and our battle is not over yet. First-time walkers, get ready for a walk that will change your life. Its time has come…it’s Rexall OneWalk to Conquer Cancer…All cancers.

We are truly grateful!

Paul's Signature

Paul Alofs (13-year committed walker)
President & CEO
The Princess Margaret Cancer Foundation

A Message From Princess Margaret Cancer Centre Leadership

Princess Margaret Building

At The Princess Margaret, we are excited to be leading a new integrated approach to cancer treatment called Personalized Cancer Medicine. As you lace up your shoes and walk for the cancer that has impacted your family the most, or choose to support the Discovery Research Fund, know that our mission at The Princess Margaret is to conquer all cancers. At Princess Margaret Cancer Centre we will not stop until we have conquered all forms of cancer. While significant progress has been made on many types of cancers through effective therapies, we see it all too clearly that we are still losing too many to this disease.

Our goal is to find tomorrow’s treatment today at The Princess Margaret and share these innovations with other cancer centres around the world. We are at the forefront of research, clinical trials and new therapeutic advancements, but we cannot do this alone. The Princess Margaret Cancer Foundation holds tours of the Cancer Centre throughout the year, we encourage you to take one of these tours and see first-hand the amazing work going on here. You can also learn more about our work by reading the Cancer Centre’s annual report at: www.theprincessmargaret.ca

Know that we will be there to walk with you and cheer you on Saturday, September 10th and that all the staff at the Princess Margaret Cancer Centre so appreciate your commitment to raising funds and walking.

Thank You!

Mary Gospodarowicz, Medical Director, Princess Margaret Cancer Centre

A Message From Dr. Tak Mak

Dr. Tak Mak

Thank you Walkers,

The 2016 Walk will be a historic point in the journey that we are all taking. With the Rexall OneWalk to Conquer Cancer, know that I will be there and continue my work for all cancers. As we announced in June 2013, we have a new target discovery and we are in Phase 1 clinical trials with our first new drug. We also have several other new drugs in the pipeline. As we move along the path of clinical trials we may find out that this new drug has impact across a number of cancers. In fact, that is my hope, that it works for many forms of cancer that people suffer from. There is a long road to walk in clinical trials and know that I continue to need you to walk and support my work and the work of my team.

You should also know that thanks to Walkers we have built the most comprehensive immune therapy program in Canada led by Dr. Pam Ohashi. This work could benefit many forms of cancers and is showing great promise.

As we continue on our journey, know that progress is being made. We know so much more today than when I started my career in the 70’s. We are in amazing era of genomic discovery and uncovering more of the insights that have eluded researchers in previous decades. We now know that there are many forms of cancer within the same type and that some forms of one cancer are more related to another form of cancer. We are discovering new cancer targets and creating new targeted drugs.

So I ask you to walk in the Rexall OneWalk to Conquer Cancer to allow me to continue the work I have committed my life to. I share your passion and your dream to one day have all cancers not be a disease that you die from but a disease you live with, for our children and our grandchildren. My team is committed and united - but we can’t do it alone.

I will see you on the 2016 walk.

Sincerely,

Dr. Tak Mak

A Message From PMCF Board Chair

Board Chair's Message

We’ve passed the halfway point in our BILLION DOLLAR CHALLENGE…and we’re getting closer.

Conquering cancer in our lifetime is a bold vision, and one that will have a huge impact. More than 40 percent of Canadians will be diagnosed with some type of cancer, so it is vital that we develop more effective treatments and continue research that will lead to a new understanding of how the disease begins and spreads.

Today, thanks to research, over 50 percent of all cancer patients live ten years or more (in the 1970s, it was 25 percent). For some types of cancers—breast, prostate and many types of lymphoma and sarcoma—the long-term survival rates are 80 percent or higher. But for other types—lung, pancreatic and ovarian—the rates remain persistently low. That is because they are all different diseases, and need specially-designed diagnostic and treatment approaches.

As one of the top 5 cancer research centres in the world, the scientists and clinicians at Princess Margaret Cancer Centre are creating tomorrow’s cancer treatment today—one disease at a time. They are conducting over 700 clinical studies of new treatment approaches, and they have a responsibility to share their success and their insight about the disease with other cancer specialists in Canada and the world. Our job is to ensure they have the equipment and the support to do their life-saving work.

At The Princess Margaret Cancer Foundation, we don’t shy away from bold visions that require big funding. In April 2012, we launched a bold BILLION DOLLAR CHALLENGE to raise the funds needed to create a new gold standard of cancer care: Personalized Cancer Medicine. We have now passed the halfway point in the challenge and have secured $576 million through philanthropy and research grants.

Personalized Cancer Medicine will include new diagnostic and treatment approaches that reflect the reality that each person’s cancer is unique and each cancer patient is a unique individual. There are already over 200 documented types of cancer, and even when two people have the same type, it varies in size, position and potential to spread. And each patient’s ability to tolerate treatment is different.

We all have a reason to support the BILLION DOLLAR CHALLENGE. Cancer will impact you or a family member, a friend or close colleague. Thank you to all of our donors who have contributed to the challenge so far. We still have a long way to go, but we know that so many share our vision of a world where cancer is controlled and prevented. We hope we can count on your continued support.

Tom Ehrlich

Tom Ehrlich's Signature

Chair, Board of Directors

What is Personalized Cancer Medicine?

At The Princess Margaret, we are excited to be leading a new integrated approach to cancer treatment called Personalized Cancer Medicine.
This approach will include using a patient’s genetic information to more precisely diagnose their cancer and tailor the most effective treatment for them.
But Personalized Cancer Medicine at The Princess Margaret is so much more. We have always focused on the individual needs of each patient and not just their disease.
That is why we have:

  • Developed award-winning clinical programs to assist our patients and their families
  • Recruited highly-skilled physicians and scientists who have the expertise to lead important research projects and clinical studies that improve the standard of care for patients
  • Built integrated teams that include engineers, bioinformatics specialists and medicinal chemists. These teams are translating new technology and discoveries into improved therapies that will help more patients sooner

Our strong culture of innovation has made this cancer centre a world leader in cancer research and treatment, and with your financial support, we will lead the way in Personalized Cancer Medicine.

Dr. Mary Gospodarowicz, Medical Director

What is Personalized Cancer Medicine?

Over the past 50 years, our scientists and physicians have learned just how complex cancer is. Every patient and every patient’s cancer is unique.

There has been a clear understanding for some time that cancer is a very different disease depending on where it originates. So today, lung cancer is treated in a different way than colon or kidney cancer, or leukemia.

But more recently, new technology and insight have allowed us to see that the disease is even more complex than that. There can be many forms of lung cancer or colon cancer, and a genetic analysis of a tumour may be required to confirm the specifics of each patient’s disease.

The Princess Margaret is one of the top 5 cancer research centres in the world with an outstanding reputation for breakthrough research, exemplary teaching and compassionate care.

We are two years into our Billion Dollar Challenge, which is a five-year initiative to help revolutionize cancer care. Over the next three years, The Princess Margaret will be continue to be creating the blueprint, developing and implementing new procedures, and setting the gold standard for Personalized Cancer Medicine for all patients at The Princess Margaret, across Canada and around the world. In addition to genetic analysis of tumours, this new approach to cancer treatment encompasses four main themes:

  • Detect
  • Diagnose
  • Target
  • Support

Detecting cancer earlier

If cancer is detected at an early stage, the prognosis for a complete remission is much improved. Our research teams are working on many early detection initiatives, including:

  • Developing and testing better imaging equipment so small tumours can be seen more clearly
  • Identifying unique ‘markers’ of cancers that can be detected in blood and serum tests

Diagnosing with more precision

New equipment and procedures that determine the specific genetic mutations or changes that gave rise to a patient’s cancer are being tested at The Princess Margaret. This information will enable the experts to recommend the optimal combination of drug and other therapies for successfully treating each patient.

Targeting treatment for each patient

Improved surgical, radiation and drug treatments will target only the cancer and leave healthy tissue alone, minimizing toxic side effects. Our scientists and doctors are testing new treatments that can more effectively detect and eradicate cancer cells leading to more durable cures.

Supporting patients and families throughout their cancer journey

Being well-informed about their disease, the treatment they will receive and the side effects that can be expected gives patients and their families more confidence, reduces anxiety and leads to improved quality of life. Our award-winning survivorship, patient education and psychosocial support programs need to be expanded so that more patients can be empowered throughout their personal cancer journey.

About Princess Margaret Cancer Centre

Princess Margaret Cancer Centre

Princess Margaret Cancer Centre is one of the top 5 cancer research centres in the world. We are the largest cancer research and clinical program in Canada. As global leaders in cancer care, we have the expertise to treat over 200 types of cancers including the rarest forms of the disease. The Princess Margaret has a rich history of research excellence, discovery and innovation. Every day, we combine our clinical strength with the research expertise of The Campbell Family Cancer Research Institute to deliver breakthrough cancer research, treatments and patient-centered care.

Because we are Canada’s largest and most comprehensive cancer research centre, The Princess Margaret is responsible for delivering the evidence and measuring the benefit of new treatments and new approaches. We are proud to lead the way in the creation and delivery of the new gold standard in cancer care: Personalized Cancer Medicine.

The Princess Margaret is…

  • A world leader in image-guided therapeutics.
  • A world leader in lung cancer research and treatment.
  • A world leader in patient survivorship program development.
  • An emerging world leader in breast cancer research and discovery.
  • An emerging world leader in immune therapy.
  • An emerging world leader in palliative care and support research.
  • An emerging world leader in Personalized Cancer Medicine.

The Princess Margaret offers comprehensive cancer care across 13 disease sites: Breast, Lung, Gastrointestinal, Gynecologic, Genitourinary, Head and Neck, Central Nervous System, Lymphoma, Sarcoma, Leukemia, Eye, Melanoma, Thyroid

2012-13 By the Numbers:

The Princess Margaret treats over 200 types of cancer through surgery, chemotherapy, radiation, psychosocial and palliative care.

Outpatient Clinic Visits: 429,608
Chemotherapy Treatments: 31,025
Radiation Treatments: 169,673
Cancer Surgeries: 6,135
Outpatient clinic visits/day*: 1,400
Stem Cell Tranplants 319
*approximated average based on 5 day week

About Princess Margaret Cancer Centre

The Princess Margaret Cancer Centre has achieved an international reputation as a global leader in the fight against cancer and delivering Personalized Cancer Medicine. The Princess Margaret, one of the top 5 cancer research centres in the world, is a member of the University Health Network, which also includes Toronto General Hospital, Toronto Western Hospital and Toronto Rehabilitation Institute. All are research hospitals affiliated with the University of Toronto. www.theprincessmargaret.ca

About The Campbell Family Cancer Research Institute

Campbell Family Cancer Research Institute

Vision

The Campbell Family Cancer Research Institute is recognized as one of the top 5 cancer research facilities in the world as measured by its number of new discoveries, the quality of its research, its reputation and its overall impact on conquering cancer in our lifetime.

Values

  • Scientific excellence
  • Relevance of research to the clinic
  • Ability to bridge disciplines
  • Dedication
  • Creativity

Background

The Campbell Family Institute for Breast Cancer Research was launched in June 2004 thanks to an extraordinarily generous gift of $25 million from the late Audrey Campbell and her three daughters. In addition, Susan Grange donated $5 million to support the innovative work of Dr. David Jaffray in the area of image-guided radiation.

The Campbell Family Cancer Research Institute, supported by the significant and long-term commitment of the Campbell Family and The Walk, is an international powerhouse at The Princess Margaret Cancer Centre. The Campbell Family Cancer Research Institute leads the world in many of the most promising areas of cancer research such as tumour metabolism, cancer stem cells, cancer genomics, proteomics, informatics and molecular imaging/guided therapeutics. The Campbell Family Institute builds on the breast cancer research work of internationally recognized Dr. Tak Mak and his team, to benefit all cancers.

The sustainable development of The Campbell Family Institute will depend on the close integration of people and resources, enabling maximum global impact in the fight against cancer.

The Campbell Family Cancer Research Institute capitalizes on the work of existing stars such as Dr. Tak Mak (t-cell receptor discovery and more recent new cancer target discovery), Dr. John Dick (cancer stem cells) and Dr. Pam Oashi (immune therapy) and a long list of distinguished researchers, to accelerate the pace of cancer research, facilitating the translation of scientific advances into new life-saving therapies that will help us in our collective efforts to CONQUER CANCER IN OUR LIFETIME.

The vision of The Campbell Family Cancer Research Institute is to continue to be recognized as one of the top 5 cancer research centres in the world as measured by its number of new discoveries, the quality of its research, its reputation and its overall impact on conquering cancer.

For more information go to: www.campbellfamilyinstitute.ca

The Princess Margaret’s Billion Dollar Challenge

Princess Margaret Building

The Princess Margaret Cancer Foundation will mark its half-way point in its BILLION DOLLAR CHALLENGE on October 15th, 2014. The Challenge is a 5-year initiative to secure $1 BILLION to create the new gold standard in cancer care: PERSONALIZED CANCER MEDICINE.

This new approach to cancer care involves finding the right treatment, for the right patient, at the right time. Our focus is to detect cancer earlier, diagnose with more precision, target treatment for each individual and support patients and their families through their cancer journey.

The Billion Dollar Challenge supports this ambitious goal. The Princess Margaret Cancer Foundation’s challenge is to raise $500 million through philanthropy over this period while our researchers are challenged to secure $500 million in research grants. We are tracking ahead of plan but every donation, every walker and every program counts as we seek to accomplish this goal.

We are enormously grateful to all those who support our vision of Personalized Cancer Medicine. To create and deliver this new model of cancer care, leaders at The Princess Margaret are recruiting scientists, clinicians and other experts to further strengthen our position in important areas such as epigenetics, clinical genomics, bio banking, computational biology, immune therapy and pathology.

The Billion Dollar Challenge will help ensure that the Princess Margaret Cancer Centre remains one of the top 5 cancer research centres in the world and leads the way in new therapies to save more lives for patients at The Princess Margaret, across Canada and around the world.

Your Impact

Princess Margaret Building

The 2015 OneWalk to Conquer Cancer raised over $7.5 million for the Princess Margaret Cancer Centre. 2016 is the second annual OneWalk in Toronto.

Funds raised through the Rexall OneWalk to Conquer Cancer support Personalized Cancer Medicine at The Princess Margaret, enabling our world-leading clinicians and researchers to detect cancers earlier, diagnose with more precision, target treatment for each patient and support patients and their families throughout the cancer journey. Princess Margaret Cancer Centre is leading the way in Personalized Cancer Medicine as one of the top 5 cancer research centres in the world.

OneWalk is The Princess Margaret’s next generation fundraiser. With OneWalk you choose to fundraise as a team or individually and designate the fundraising dollars and you choose to cancer the cancer that matters most to you.

When a participant registers, they select a cancer fund that their dollars raised will support, such as: Discovery Research, Breast, Gynecologic, Lung, Gastrointestinal, Hepatobiliary, Genitourinary, Blood Cancers, Endocrine, Skin Cancer and Melanoma, Head and Neck Cancers, Central Nervous System Cancers, Brain and Eye Cancer, Sarcoma, Childhood Cancers, Supportive Care and Patient Education.

Since 2003, supporters of The Princess Margaret have been walking to help conquer cancer in all its forms. In 12 years, The Weekend to End Women’s Cancers raised over $148 million for the Princess Margaret Cancer Centre.

Princess Margaret Cancer Centre is one of the top 5 cancer research centres in the world. We are the largest cancer research and clinical program in Canada. As global leaders in cancer care, we have the expertise to treat over 200 types of cancers including the rarest forms of the disease.

The Princess Margaret has a rich history of research excellence, discovery and innovation. Every day, we combine our clinical strength with the research expertise of The Campbell Family Cancer Research Institute to deliver breakthrough cancer research, treatments and patient-centered care.

Because we are Canada’s largest and most comprehensive cancer research centre, The Princess Margaret is responsible for delivering the evidence and measuring the benefit of new treatments and new approaches. We are proud to lead the way in the creation and delivery of the new gold standard in cancer care: Personalized Cancer Medicine.

This new model of patient care will allow us to detect cancer earlier, diagnose cancer with more precision, target treatment more effectively and support patients and families through their cancer journey. By leveraging our research and clinical strength, we will continue to lead the way and deliver the evidence that will create Personalized Cancer Medicine for patients at The Princess Margaret, across Canada and around the world.

The new discoveries and innovative cancer therapies that are changing cancer care for patients globally are happening right here in Canada, at The Princess Margaret.

The Princess Margaret is…

  • the world leader in cancer stem cell research
  • a world leader in image-guided therapeutics
  • a world leader in lung cancer research and treatment
  • a world leader in patient survivorship program development
  • an emerging leader in breast cancer research and discovery

2014 – 2015 By the Numbers (approx average based on 5 day week):

Princess Margaret Cancer Centre treats over 200 types of cancer through surgery, chemotherapy, radiation, psychosocial and palliative care.

  • New patients: 18,003
  • Outpatient chemo visits: 34,851
  • Radiation visits: 93,379
  • Outpatient Clinic visits/day*: 1,652
  • Stem cell transplants: 416
  • Surgeries: 6,206

Funds raised since 2003 have powered a range of cancer research, clinical enhancements survivorship and other programs at Princess Margaret Cancer Centre:

Research:

$54.7 million to The Campbell Family Institute for Breast Cancer Research led by Dr. Tak Mak, with 11 Principal Investigators and over 130 staff.

  • Dr. Tak Mak and his team of researchers from The Campbell Family Research Institute announced a new “sharpshooter” cancer drug that will target an enzyme called PLK4, which plays a crucial role in the process of cancer cell division. On July 18, 2013 Dr. Mak and his team gained clearance by Health Canada to proceed with the drug into Phase I Clinical Trial in Canada.*
  • Scientists led by Drs. Mona Gauthier and Tak Mak have discovered how BRCA1 gene mutations specifically predispose women to breast and ovarian cancers.
  • Dr. Pamela Ohashi’s research into T-cell activation and boosting the immune system to fight tumors. Her work focuses on understanding the signaling pathways of T-cells to help activate, direct and enhance anti-tumor responses in cancer. Clinical trial of her team’s adoptive cell therapy began in the Fall of 2013. Dr. Pamela Ohashi’s research into T-cell activation and immunotherapy to fight breast tumours, is part of The Campbell Family Institute funding.
  • $7.4 million to purchase cutting edge research equipment and support breast cancer research activities in the PMH research expansion at MaRS (Medical and Related Science).
  • $3 million to create The Weekend to End Breast Cancer Chair in Breast Cancer Research, held by Dr. Tak Mak, a world renowned cancer research scientist.
  • $1.5 million to the Walker Innovation Program, which supports researchers and new ideas that have the potential for advancing scientific knowledge of breast cancer.
  • $2.1 million to support Dr. Norman Boyd’s research into breast cancer prevention, focusing on the understanding of mammographic density as a risk factor.
  • $1.8 million to support Mass Spectrometer program
  • $500,000 to support research at The Campbell Family Cancer Research Institute for equipment, lab expenses, research and staff related expenses and research operations.

Clinical Enhancements:

  • $3.9 million toward a comprehensive breast imaging program and the purchase of a breast MRI and digital mammography machine.
  • $3 million toward a newly revamped and re-designed M. Lau Breast Centre that provides complete care for breast cancer patients.
  • $2.9 million to support clinical trials for breast cancer patients. and $500,000 for fellowship program
  • $2 million to support an extensive Tumour Bank, database maintenance and pathology renovations.
  • $1.3 million to support Dr. David McCready’s rapid diagnosis pilot study, which is now The Gattuso Rapid Diagnostic Centre and sees up to 1,500 patients a year.
  • $550,000 to support the clinical trial of intraoperative radiation therapy, led by Dr. David McCready and Dr. Anthony Fyles.
  • $250,000 toward the design and creation of the new Conway Chemotherapy and Transfusion Centre, the largest centre of its kind in North America.
  • $880,000 to support the surgical robotics program for gynecologic cancer patients.
  • $160,000 toward the Familial Ovarian Cancer Clinic, which now also provides genetic counselling for breast cancer patients.
  • $3.4 million for other clinical enhancements and genetics research programs
  • $2.5 million to support Princess Margaret’s Space Transformation which is a multi-phase project that will create a transformative environment for Personalized Cancer Medicine.
  • $130,000 towards grant matching program

Survivorship:

  • $11 million for the establishment and continued support of the first in-hospital Survivorship Clinic and Program in Canada. This includes ELLICSR, a 12,000-square-foot innovative research centre, and caringvoices.ca, an award-winning online community for survivors and their families.
  • $1 million to provide reconstructive breast surgery for women who have had breast cancer.

The Princess Margaret Cancer Foundation Fund:

  • $3.1 million to support the Princess Margaret Cancer Foundation Fund
*New cancer drug development is a long and risk-filled process. We are very encouraged by this discovery and reaching this major milestone. The drug discovery from Dr. Tak Mak and Dr. Dennis Slamon announced by The Princess Margaret Cancer Foundation in June 2013 has been cleared by Health Canada and the University Health Network Research Ethics Board, and is in clinical trials. For more information please visit www.canadiancancertrials.ca.